Background The multiple pathways that are involved in neuroendocrine differentiation (NED) in prostate cancer (PCa) are poorly elucidated. Evidence suggests that several environmental triggers induce NED leading to the adaptation of PCa to its close environment to maintain cell proliferation. Nevertheless, there is conflicting evidence regarding the prognostic role of NED in PCa. Methods In […]
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A web-based survey was conducted between 15 August and 15 September 2013 by members of the Prostate Cancer Working Group of the Young Academic Urologists Working Party of the European Association of Urology (EAU). A specific, 29-item multiple-choice questionnaire covering the whole spectrum of diagnosis, staging and treatment of high-risk PCa was e-mailed to all […]
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A computerized tomography (CT) scan represents the most commonly used imaging technique for diagnosis. Magnetic resonance imaging (MRI) is unable to differentiate more accurately between benign and malignant retroperitoneal fibrosis (RF) than a CT scan. Biopsy remains the most reliable diagnostic tool for IRF. However, the histological characteristics of IRF are not yet well-defined and […]
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What is the optimal definition of misclassification in patients with very low-risk prostate cancer
The risk of unfavorable prostate cancer in active surveillance (AS) candidates is nonnegligible. However, what represents an adverse pathologic outcome in this setting is unknown. We aimed at assessing the optimal definition of misclassification and its effect on recurrence in AS candidates treated with radical prostatectomy (RP). Among patients eligible for AS treated with RP, […]
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Cytotoxic antibodies monitoring in kidney transplantation – their clinical relevance and challenges
Introduction: The key of the successful renal transplantation is the ability to identify the best immunological match between donor and recipient considering the possibility of rejection phenomenon. The aim was to identify class I and/or class II cytotoxic antibodies in renaltransplanted patients in order to assess the immunological potential for prevention of subclinical or acute […]
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Biopsia de próstata sistemática guiada por ecografía por saturación y utilizando plantilla
En biopsia inicial, hay un aumento de la evidencia de que el esquema de saturación se asocia con una tasa de detección de CaP mayor en comparación con el estándar en varones con valores de PSA menores(< 10 ng/ml), próstatas más grandes (>40 cc), o valores de densidad del PSA menores (
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Can we expand active surveillance criteria to include biopsy Gleason 3+4 prostate cancer?
The final pathologic Gleason score was 3+3 = 6 in 8%, 3+4 = 7 in 67%, 4+3 = 7 in 20%, and 8 to 10 in 5% cases. The overall rate of unfavorable disease (upgrading or advanced stage or both) was 46%. In multivariable analysis, prostate-specific antigen (PSA) level>10 ng/ml, PSA density (PSAD) >0.15 ng/ml/g, clinical stage […]
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Tuberculosis of the penis represents an uncommon disease, especially in the European Countries, since the introduction of tuberculostatics [1]. It may be presented as an extrapulmonary form of tuberculosis, or, in rare cases, as primary lesion of the gland after contact with female genital ulcers [2, 3]. The main differential diagnosis of this entity is […]
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